ChimeRMarker automated chimerism analysis software integrates speed and accuracy with a biologist-friendly interface. The software can be used to monitor chimerism level in both an allogeneic stem cells transplant (SCT) or a hematopoietic stem cells transplant (HSCT), bone marrow transplant (BMT, post bone marrow engraftment), and cord and peripheral blood stem cells transplant (PBSCT) samples.
Vendor
Dotmatics
Company Website
Overview
ChimeRMarker Automated Chimerism Analysis Software is designed to integrate speed and accuracy with a biologist-friendly interface. This software is used to monitor chimerism levels in various types of stem cell transplants, including allogeneic stem cells transplant (SCT), hematopoietic stem cells transplant (HSCT), bone marrow transplant (BMT), and cord and peripheral blood stem cells transplant (PBSCT) samples. ChimeRMarker provides complete chimerism detection, long-term monitoring, and quantification in one program, significantly increasing analysis capacity by 20-30% annually. The software offers accurate, rapid genotyping and chimerism analysis with documented time savings of up to 85%. It automatically identifies donor and recipient peaks in post-BMT samples, calculates percent chimerism, and provides quality metrics for single donor or double donor cases. ChimeRMarker also supports longitudinal monitoring post-BMT, with multi-lineage capabilities for analyzing T-cells, B-cells, and other cell type populations.
Features
- Platform Compatibility: Compatible with ABI®PRISM, Applied Biosystems® SeqStudio, Hitachi High-Tech Compact CE Sequencer DS3000, Promega Spectrum Compact CE Systems, and Syntol Nanophore® 05 genetic analyzers.
- Automated Analysis: Provides automated routine chimerism calculations for unique and shared peaks, increasing throughput and reducing errors.
- Longitudinal Monitoring: Supports comparison of samples at different time points for comprehensive chimerism analysis.
- Multi-Lineage Capabilities: Analyzes chimerism in various cell types, including T-cells and B-cells.
- Maternal Cell Contamination (MCC) Application: Includes a linked MCC application for comprehensive analysis.
- Flexible Reporting: Offers flexible reporting options, including automatic labeling of donor, recipient, and shared peaks in chimeric samples.
- Quality Metrics: Provides detailed quality metrics, including coefficient of variation, standard deviation, average chimerism percentage, measurement error, and locus error.