Achieve best-in-class accuracy for your genomic analysis

Accelerate confident decision-making in Oncology and Rare & Inherited Disorders with end-to-end genomics workflows for streamlined sequencing data analysis and interpretation. Reach accurate variant detection, simplified variant prioritization, and expedited reporting.

Overcome bottlenecks and increase confidence in your results

SOPHiA DDM™ is a leading IVDR-certified* genomics platform that leverages AI algorithms to accurately pinpoint signals within noisy, complex next-generation-sequencing (NGS) datasets. It seamlessly integrates into any genomics workflow to identify causative variants. *When used in Dx mode

Best-in-class accuracy

Detect challenging variants with high confidence using our AI/machine learning algorithms, which excel at calling complex and diverse variant types.

Universal compatibility

Effortlessly integrate our technology-agnostic analytical platform into your existing laboratory setup for any Oncology or Rare & Inherited Disorder application.

Accelerated workflows

Dramatically expedite your interpretation by removing genomic variant analysis barriers with the SOPHiA DDM™’s annotation and pre-classification capabilities.

From data to decisions, faster than ever

1. Data upload

Securely log in to our cloud-based platform with 2-step verification. Quickly upload FASTQ files and select from performance pipelines tailored to sample type, chemistry, enrichment kit, and sequencer.

2. Variant calling and annotation

Assess multiple variant types within a single experiment without needing deep bioinformatics expertise. Our somatic and germline pipelines are optimized for targeted to genome-sized applications and provide comprehensive annotation with up-to-date information from >55 world-renowned curated databases, guidelines, and predictors.

3. Prioritization and filtering

Leverage machine learning and guideline-driven ranking to automatically assign pathogenicity levels to identified variants. Through our user-friendly interface, easily apply multiple filtering functions to focus on disease-specific variants, create custom filtering strategies, and/or filter by inheritance mode.

4. Exploration and interpretation

Add context to your variant interpretation. Flag variants and share insights with your disease-specific peer network or the entire SOPHiA GENETICS Community. Enhance your interpretation with direct access to the add-on modules OncoPortal™ and Alamut™ Visual Plus, that provide deeper, more comprehensive insights into your findings.

5. Reporting

Easily generate customized reports using provided templates. Reports are CAP- and CLIA-compliant and include guideline-driven information to support decision making.