Quantitative Systems Pharmacology (QSP) Software is designed to enhance the efficiency and success rate of drug development programs by supporting the optimization of clinical trial design and clinical development decision-making. This solution empowers R&D teams to allocate their budget more effectively towards molecules and compounds with the highest likelihood of success in clinical trials, ultimately increasing the probability of bringing successful drugs to market. The software is built by experienced scientists who possess decades of expertise in integrating complex scientific disciplines, including biochemistry, cellular interactions, physiology, and pharmacology, with the necessary mathematics and computer science. This interdisciplinary approach results in robust modeling and simulation platforms that provide accurate predictions. The platform's predictions are rigorously validated through collaborations with industry partners, ensuring their reliability for guiding critical drug development programs. Beyond providing industry-leading QSP software for in-house experts, the offering also includes QSP modeling support from dedicated scientists, catering to teams that may require external expertise. The software provides a comprehensive collection of validated QSP models across numerous disease and toxicologic areas, setting an industry standard for depth and breadth of application.

Features & Benefits

• Clinical Development Optimization
  • Supports the optimization of clinical trial design and clinical development decision-making, helping to increase the likelihood of success and optimize R&D budget allocation for efficacy and safety.
• Robust Modeling & Simulation Platform
  • Integrates biochemistry, cellular interactions, physiology, and pharmacology with advanced mathematics and computer science to develop highly robust modeling and simulation capabilities.
• Validated Predictive Accuracy
  • Ensures the most accurate predictions for drug development programs through validation efforts with industry partners.
• Comprehensive Therapeutic Area Expertise
  • Offers a collection of validated QSP models across a wide range of disease and toxicologic areas.
  • Liver & Kidney Safety (Drug-induced acute kidney injury, Drug-induced liver injury (DILI))
  • Metabolic & Cardiac Conditions (Cardiac wound healing and fibrosis, Hypertension, Myocardial infarction recovery, MASLD/MASH, Obesity, Renal Diseases, Type 2 diabetes)
  • Inflammatory Disease (Fibrotic & Autoimmune) (Atopic dermatitis, Complement pathway diseases, Dermatomyositis, Gout, Idiopathic pulmonary fibrosis (IPF) and interstitial lung disease (ILD), Inflammatory bowel diseases, Psoriasis & Psoriatic arthritis, Rheumatoid arthritis (RA), Lupus (SLE & CLE))
  • Immuno-Oncology (Acute myeloid leukemia (AML), Multiple myeloma (MM), Solid tumor (NSCLC, Melanoma, prostate cancer, colorectal cancer), Diffuse large B-cell lymphoma (DLBCL))
• Core Modeling Platforms
  • Includes specialized modeling tools such as DILIsym® and RENAsym®.