ONI's Pathogens Hub centers around the Nanoimager, a compact super-resolution microscopy system specifically designed for pathogen research in biosafety environments. The platform combines advanced imaging hardware with NimOS software to enable real-time localization rendering and quantification of viral particle characteristics including size, diffusion rates, and concentration. The system's unprecedented stability and compact design allows it to operate within biosafety cabinets, providing researchers with a safe environment for studying infectious agents. With resolution capabilities reaching 20 nanometers, the platform supports both super-resolution microscopy and live-cell imaging, enabling detailed characterization of pathogen behavior in host cells. The system accommodates up to four molecular species simultaneously using different fluorescent markers and integrates with microfluidics for drug and vaccine testing applications.

Key Features

Super-Resolution Imaging Capabilities Delivers high-resolution imaging with precision down to 20 nanometers.

• Enables detailed visualization of viral particles and pathogens
• Supports both super-resolution microscopy and live-cell imaging modes

Real-Time Analysis with NimOS Software Dedicated software platform for immediate data processing and visualization.

• Provides real-time localization rendering of viral particles
• Quantifies particle size, diffusion rates, and concentration instantly

Biosafety Cabinet Compatibility Compact, stable design optimized for operation in controlled safety environments.

• Minimizes vibrations for stable imaging in biosafety cabinets
• Enables safe handling of infectious agents during microscopy

Multi-Parameter Detection Supports simultaneous analysis of multiple molecular targets.

• Accommodates up to four molecular species using different fluorescent markers
• Enables comprehensive pathogen characterization in single experiments

Microfluidics Integration Compatible with microfluidic systems for advanced testing applications.

• Supports drug and vaccine testing workflows
• Enables in vivo testing of compound mode of action, dosage, and efficiency

Benefits

Enhanced Safety in Pathogen Research Enables high-quality microscopy within biosafety environments.

• Reduces risk exposure while maintaining research capabilities
• Provides peace of mind for researchers working with infectious agents

Accelerated Diagnostic and Therapeutic Development Facilitates rapid characterization of pathogens and testing of interventions.

• Supports development of better diagnostics, vaccines, and antiviral treatments
• Enables both single-cell and population-level analysis

Comprehensive Pathogen Analysis Delivers detailed insights into pathogen behavior and host interactions.

• Measures pathogen behavior in host cells with high precision
• Supports multi-parameter analysis for complete characterization

User-Friendly Operation Turn-key solution designed for accessibility and ease of use.

• Intuitive system operation requiring minimal specialized training
• Combines ultimate super-resolution techniques in accessible format