The ONI LNP Profiler Kit with AutoLNP is a fully integrated platform designed for the quantitative characterization of lipid nanoparticles (LNPs) in pharmaceutical and biotechnological research. Combining optimized reagents, precision imaging hardware, and advanced machine learning-driven software, the system enables rapid, high-resolution, single-particle analysis of LNP size, morphology, encapsulation efficiency, and ligand loading. The platform streamlines the entire workflow from sample preparation to data interpretation, supporting high-throughput screening and robust quality control. It is specifically tailored for drug developers, biopharmaceutical companies, and quality control teams working on RNA therapeutics, gene editing, and targeted drug delivery systems, providing actionable insights for formulation optimization and regulatory compliance.

Key Features

Super-Resolution Imaging and Sizing Enables visualization and measurement of LNPs at nanometer-scale precision.

• Detects individual LNPs in complex samples.
• Provides detailed morphology and size distribution data.

Automated, ML-Driven Analysis AutoLNP software automates image processing and quantitative analysis.

• Delivers reproducible, high-throughput results with minimal manual intervention.
• Reduces human error and assay variability.

Comprehensive LNP Characterization Assesses LNP size, composition, encapsulation efficiency, and ligand loading.

• Supports multi-parameter analysis in a single workflow.
• Optimized for various PEG-based LNP formulations.

Rapid, High-Throughput Screening Processes tens of thousands of particles per experiment in a single day.

• Accelerates formulation development and quality control.
• Suitable for regulatory testing and manufacturing environments.

Streamlined, Robust Assay Workflow Integrated reagents and protocols for consistent, easy-to-use operation.

• No specialized training required for routine use.
• Ensures reproducibility across different sample types.

Benefits

Accelerated Drug Development Enables faster, data-driven optimization of LNP formulations.

• Reduces development timelines for RNA therapeutics and vaccines.
• Facilitates rapid decision-making in research and manufacturing.

Improved Data Quality and Reproducibility Provides single-particle, quantitative data with high sensitivity.

• Minimizes variability compared to traditional bulk assays.
• Enhances confidence in regulatory submissions and quality control.

Comprehensive Insight into LNP Performance Delivers actionable information on payload distribution, particle integrity, and ligand targeting.

• Supports deeper understanding of LNP mechanisms of action.
• Informs formulation strategies for improved therapeutic delivery.