IPFsym® is a sophisticated mechanistic, mathematical model specifically designed for Idiopathic Pulmonary Fibrosis (IPF), a fatal lung disease characterized by progressive loss of lung function. Leveraging extensive experience in modeling other fibrotic diseases, IPFsym aims to simulate lung fibrosis and other aspects of IPF pathophysiology. This QSP modeling software is developed to enhance the efficiency of the clinical development process within the pharmaceutical industry, as QSP modeling has been proven to accelerate drug discovery and development. The software achieves this by combining predictions of compound exposure with the pharmacodynamic characteristics of a compound, evaluating how these factors can produce efficacy across a diverse range of patients with pathophysiologic variability. IPFsym v1A is available for in-house use through corporate software licenses, offering transparency with open access to equations and parameter values for viewing and modification. It requires MATLAB software, available separately. Alternatively, organizations can engage in an IPFsym consulting project for tailored support. The software is a downloadable computer application for conducting simulations of various compounds, including drugs and chemicals, to assess and model their effects on the respiratory system, particularly the lungs.

Features & Benefits

• Mechanistic QSP Modeling
  • Provides a state-of-the-art mechanistic, mathematical model of Idiopathic Pulmonary Fibrosis (IPF) to simulate disease progression and drug effects.
• Accelerated Clinical Development
  • Designed to make the clinical development process more efficient by providing predictive insights into compound efficacy across patient variability.
• Compound Simulation & Evaluation
  • Enables comprehensive simulations of drugs and chemicals to evaluate and model their specific effects on the respiratory system and lungs.
• Open & Customizable Model
  • Offers transparency with open access to equations and parameter values, allowing for viewing and modification by users.
• Flexible Deployment & Support
  • Available for in-house use via corporate software licenses or through dedicated consulting projects, requiring MATLAB software.