The Bone Microarchitecture Analysis (BMA) Add-On is a software module for the Analyze platform, designed to process and analyze microCT data of bone specimens. It automates the segmentation of cortical and trabecular bone regions and generates a comprehensive set of quantitative bone morphometric measurements, supporting pre-clinical research in bone structure and quality assessment.

Key Features

Automated Bone Segmentation Automatically separates cortical shell, cortical pores, and trabecular tissue.

• Identifies and isolates bone of interest
• Ensures correct anatomical orientation

Trabecular and Cortical Analysis Performs detailed segmentation and measurement of both trabecular and cortical bone regions.

• Distinguishes trabecular bone and intra-trabecular space
• Measures cortical area, thickness, porosity, and more

Comprehensive Quantitative Metrics Calculates and exports a wide range of bone morphometric indices.

• Outputs metrics such as bone volume, surface, density, connectivity, and anisotropy
• Results available in CSV format for further analysis

Bone Mineral Density Conversion Provides utility to convert CT numbers (Hounsfield Units) to Bone Mineral Density (BMD).

• Facilitates comparison across studies
• Outputs BMD in mg/CC

Preprocessing Tools Included Supports data preparation for accurate analysis.

• Tools for isovolumetric adjustment and anatomical orientation
• Handles multi-bone datasets

Benefits

Efficient and Reproducible Bone Analysis Streamlines microCT data processing for research efficiency.

• Reduces manual segmentation time
• Standardizes analysis workflow for consistency

Detailed Bone Quality Assessment Enables in-depth evaluation of bone microarchitecture.

• Supports pre-clinical studies of bone health, disease, and treatment effects
• Provides metrics aligned with established research standards